SQL cluster with VM of different size at DR site

I have a primary site at Azure East-US-2 region and my DR site is at Azure paired zone in Central-US.
Now in East-US-2, G-series machines are available but no such machines available in Central-US zone. I really want to use G-series VM's for SQL server as the workload is more memory intensive and less cpu intensive. 
So can I create a cluster with 2 G-Series SQL nodes at primary site and 1 D-series SQL node at DR site? If it's possible then will I face any problem because of this configuration in future?